From the May 31, 2005 article published on www.cidrap.umn.edu
Read the full article here.

“In an initial cell-culture experiment, treatment with resveratrol at 20 mcg/mL reduced flu virus replication 90%, and treatment with 40 mcg/mL blocked replication completely.”

The researchers also tested the effects of starting resveratrol treatment at different intervals after infecting cells with the virus. Treatment was most effective—reducing viral growth 87.5%—when treatment began 3 hours after virus exposure. Effects were lower but still significant when treatment began 6 hours after infection, and treatment had no significant benefit if delayed until 9 hours after infection.

Given these and other findings, the researchers concluded that resveratrol interferes with the manufacture of proteins made late in the viral replication process, such as hemagglutinin, and limits the transport of viral ribonucleoproteins from the cell nucleus to the cytoplasm. The authors also determined that the molecular mechanism for resveratrol’s effects has to do with the inhibition of protein kinase C activity and its dependent pathways.

In the tests on mice, the researchers found that resveratrol treatment increased survival by 40% in treated mice, compared with mice that received a placebo. The level of virus found in the lungs 6 days after infection was 98% lower in treated mice than in the placebo group.

“We have shown that RV [resveratrol], a natural polyphenol whose concentration in red wine is 1.5-3.0 mg/L, can inhibit the in vitro and in vivo replication of influenza A virus without producing any significant toxicity,” the article states.

The apparent ability of resveratrol to block host-cell functions that flu viruses rely on offers important advantages, the researchers say. Compared with existing anti-flu drugs, resveratrol would be less likely to induce resistance by flu viruses, and it would probably be effective for all types and strains of flu virus.

Rezilience is 100mg of trans-resveratrol manufactured under strict conditions for the highest potency by Capsugel®, a subsidiary of Pfizer® and produced in an oxygen free, nitrogen rich environment and sealed in opaque capsules made of chlorophyll.

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New research published in the Federation of American Societies for Experimental Biology (FASEB) Journal, August 2009 print issue, explains how resveratrol affects inflammation and shows how it can used to treat inflammatory diseases like appendicitis, peritonitis, and systemic sepsis.

Read the full article from www.sciencedaily.com

“The therapeutic potential of red wine has been bottled up for thousands of years and now that scientists have uncorked its secrets, they find that studies of how resveratrol works can lead to new treatments for life-threatening inflammation.”
- Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal

Resveratrol is a very delicate molecule which can convert very rapidly from what is called Trans-Resveratrol to its lesser form cis-Resveratrol, as quickly as 15 minutes when exposed to light, oxygen, or heat. Trans-Resveratrol is the only form of Resveratrol that has been shown to activate the sirtuin 1 DNA-repair gene.

The problem with manufacturing this delicate molecule is that what you start out with and end up with may be two different things.

Resveratrol is manufactured and sold in a number of different forms: solid tablets, pills, liquid, or capsules.

Imagine the manufacturing of the pill form. It starts out in powder form and then is compressed into a pill. You may have seen footage on TV showing pills going down the conveyer belt and bouncing around before they are dropped into bottles and then sealed. This whole process has exposed the product to light and oxygen. Even after opening the sealed bottle the product is once again being exposed to oxygen and light.

The liquid form of Resveratrol also suffers the same consequences. Even if the liquid form is manufactured in an oxygen-free environment, once you open the container you have just exposed it to oxygen.

Think of a bottle of wine. If you have ever tried to drink some wine that was opened five days earlier, you know what I talking about. It has degraded in taste and quality. There are many products on the market that come in capsule form. The problem here is that those products start out in powder form and are compressed into capsules that are not airtight or sealed, thereby exposing the product to the degrading effects of light and oxygen.

REZILIENCE is a unique product of 100mg of Trans-Resveratrol that is manufactured in an oxygen-free, nitrogen-rich, environment and sealed in opaque capsules made of chlorophyll under stringent clinical and environmental conditions by CAPSUGEL®, a subsidiary of PFIZER, using their patented process.

REZILIENCE has gone the extra mile by having each individual capsule sealed in blister packs to ensure the highest quality of Resveratrol achievable.