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From the May 31, 2005 article published on www.cidrap.umn.edu
Read the full article here.
“In an initial cell-culture experiment, treatment with resveratrol at 20 mcg/mL reduced flu virus replication 90%, and treatment with 40 mcg/mL blocked replication completely.”
The researchers also tested the effects of starting resveratrol treatment at different intervals after infecting cells with the virus. Treatment was most effective—reducing viral growth 87.5%—when treatment began 3 hours after virus exposure. Effects were lower but still significant when treatment began 6 hours after infection, and treatment had no significant benefit if delayed until 9 hours after infection.
Given these and other findings, the researchers concluded that resveratrol interferes with the manufacture of proteins made late in the viral replication process, such as hemagglutinin, and limits the transport of viral ribonucleoproteins from the cell nucleus to the cytoplasm. The authors also determined that the molecular mechanism for resveratrol’s effects has to do with the inhibition of protein kinase C activity and its dependent pathways.
In the tests on mice, the researchers found that resveratrol treatment increased survival by 40% in treated mice, compared with mice that received a placebo. The level of virus found in the lungs 6 days after infection was 98% lower in treated mice than in the placebo group.
“We have shown that RV [resveratrol], a natural polyphenol whose concentration in red wine is 1.5-3.0 mg/L, can inhibit the in vitro and in vivo replication of influenza A virus without producing any significant toxicity,” the article states.
The apparent ability of resveratrol to block host-cell functions that flu viruses rely on offers important advantages, the researchers say. Compared with existing anti-flu drugs, resveratrol would be less likely to induce resistance by flu viruses, and it would probably be effective for all types and strains of flu virus.
Rezilience is 100mg of trans-resveratrol manufactured under strict conditions for the highest potency by Capsugel®, a subsidiary of Pfizer® and produced in an oxygen free, nitrogen rich environment and sealed in opaque capsules made of chlorophyll.